PhD fellowship in chemical methods for half-life extension of peptides

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Employment type: FULLTIME. Requisition: 3107693. The Department of Chemistry, Section for Chemical Biology invites applicants for a PhD fellowship in chemical methods for half-life extension of therapeutic peptides. The project is part of the research project “New strategies for half-life extension of peptide therapeutics”, which is financed by a Distinguished Innovator Grant from the Novo Nordisk Foundation. Start date is (expected to be) January 1st 2027 or as soon as possible thereafter. The project The PhD project aims at developing new methods to chemically modify peptide therapeutics to enhance and prolong their effect in the body. The first goal is to develop novel cleavable linkages that activate the peptide when the bond is broken. The second goal is to develop new methods for taking a native peptide and chemically modify it locally so that it becomes more resistant to breakdown by enzymes. Who are we looking for? We are looking for candidates within the fields of chemical biology, synthetic organic chemistry, peptide science, and medicinal chemistry. Applicants can have a background in synthetic bioorganic chemistry with a focus on peptides and proteins, preferably also experience with chemo-selective conjugation chemistries, medicinal chemistry of biopharmaceuticals. Experience with synthesis and characterization of bioconjugates would be advantageous1 …

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