PhD scholarship in T Cell Immunoinformatics - DTU Health Tech

Kort om jobbet

The Section of Bioinformatics, DTU Health Tech is world leading within Immunoinformatics and Machine-Learning. Currently, we are seeking a highly talented and motivated PhD student within the field of T Cell Immunoinformatics. Responsibilities and qualifications The immune system defends us against pathogens through immune cells specialized to mount precise and individualized responses. The dynamic behavior of the immune cell repertoire vitally determines health and disease outcomes. A key driver of this dynamism is the interaction between T cell receptors (TCR) and pathogen proteins. Considerable efforts have been devoted to developing computational models that predict TCR interactions. Despite these advances, predictive performance remains limited, and accurately characterizing TCR recognition continues to be a major challenge. We hypothesize that this is due to three interconnected factors: (i) the immense diversity of TCRs, (ii) the limited quantity and quality of available data, which is heavily biased toward a small number of well-studied epitopes, and (iii) the lack of deep learning (DL) approaches specifically designed to capture the unique characteristics of TCR interactions1 …

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